Electrocardiographic Characteristics and SCN5A Mutations in Idiopathic Ventricular Fibrillation Associated With Early Repolarization
نویسندگان
چکیده
Hiroshi Watanabe, MD, PhD, FESC; Akihiko Nogami, MD, PhD; Kimie Ohkubo, MD, PhD; Hiro Kawata, MD, PhD; Yuka Hayashi, MD; Taisuke Ishikawa, DVM; Takeru Makiyama, MD, PhD; Satomi Nagao, MD; Nobue Yagihara, MD; Naofumi Takehara, MD, PhD; Yuichiro Kawamura, MD, PhD; Akinori Sato, MD, PhD; Kazuki Okamura, MD, PhD; Yukio Hosaka, MD, PhD; Masahito Sato, MD, PhD; Satoki Fukae, MD, PhD; Masaomi Chinushi, MD, PhD; Hirotaka Oda, MD, PhD; Masaaki Okabe, MD, PhD; Akinori Kimura, MD, PhD; Koji Maemura, MD, PhD; Ichiro Watanabe, MD, PhD, FHRS; Shiro Kamakura, MD, PhD; Minoru Horie, MD, PhD; Yoshifusa Aizawa, MD, PhD; Wataru Shimizu, MD, PhD; Naomasa Makita, MD, PhD
منابع مشابه
Letter by Casado-Arroyo et al regarding article, "Electrocardiographic characteristics and SCN5A mutations in idiopathic ventricular fibrillation associated with early repolarization".
BACKGROUND Recently, we and others reported that early repolarization (J wave) is associated with idiopathic ventricular fibrillation. However, its clinical and genetic characteristics are unclear. METHODS AND RESULTS This study included 50 patients (44 men; age, 45 ± 17 years) with idiopathic ventricular fibrillation associated with early repolarization, and 250 age- and sex-matched healthy ...
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7. Burashnikov E, Pfeiffer R, Barajas-Martínez H, et al. Mutations in the cardiac L-type calcium channel associated with inherited J-wave syndromes and sudden cardiac death. Heart Rhythm. 2010;7:1872--82. 8. Chopra N, Knollmann BC. Genetics of sudden cardiac death syndromes. Curr Opin Cardiol. 2011;26:196--203. 9. Watanabe H, Nogami A, Ohkubo K, et al. Electrocardiographic characteristics and S...
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Introduction Early repolarization (ER) is a common electrocardiographic finding and is diagnosed by the presence of a J-wave amplitude of Z0.1 mV in Z2 contiguous inferior or lateral leads of a standard 12-lead electrocardiogram (ECG), which is manifested as QRS slurring or notching. The ER pattern is observed in 1%–13% of cases in the general population and is mainly thought to be benign. Howe...
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BACKGROUND Mutations in genes encoding the L-type cardiac calcium channel (LTCC) are associated with various types of inherited arrhythmias, including Brugada syndrome (BrS). However, the frequency in Asian populations remains unknown. This study aimed to elucidate disease-causing mutations in LTCC-related genes in Japanese patients diagnosed as BrS or idiopathic ventricular fibrillation (IVF),...
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In the great majority of cases the ECG pattern of early repolarization (ERP) is a benign phenomenon observed predominantly in teenagers, young adults, male athletes and the black race. The universally accepted criterion for its diagnosis is the presence, in at least two adjoining leads, of ≥ 1 mm or 0.1 mV ST segment elevation. In benign ERP reciprocal ST segment changes are possible only in le...
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